Neoplasms in domestic animals: a review of experimental and spontaneous carcinogenesis.

Studying humane endpoints in a rat model of mammary carcinogenesis

Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...

Spontaneous neoplasms in sheep with report of cases of melanoma, mesothelioma and lymphosarcoma

Toxicity of Peganum harmala: Review and a Case Report

Peganum harmala L. is a plant, which grows in semi-arid rangeland. The plant is used traditionally as an emmenagogue and an abortifacient agent in the Middle East and North Africa. All parts of plant are thought to be toxic and sever intoxication occurs in domestic animals. Digestive and nervous syndromes have been observed in animals that consume sub-lethal amount of the plant. The toxicated a...

مطالعه ی مروری بر روی اثر اسیدهای چرب لینولئیک کونژوگه(Conjugated linoleic acids) بر مهار سلولهای سرطانی و مکانیسم های احتمالی تاثیر آنها

Conjugated Linoleic Acids (CLAs) are composed of positional and stereo isomers of octadecadienoate (18:2). They are found in foods derived from ruminants (beef and lamb as well as dairy products from these sources). When a mixture of isomers is fed to experimental animals, chemically induced cancer, tumorogenesis in mammary gland, colon and skin is decreased. Mechanisms of inhibition of carcino...

Biochemical properties and biological functions of the enzyme rhodanese in domestic animals

The enzyme rhodanese (thiosulfate: cyanide sulfurtransferase) is a ubiquitous enzyme and its activity ispresent in all living organisms. Many functions including cyanide detoxification, formation of iron-sulfurcenters and participation in energy metabolism have been attributed to this enzyme. The enzyme catalyzesthe transfer of a sulfur atom from sulfane containing compounds (such as thiosulfat...